Concentration-Time Profiles of Gamma-Hydroxybutyrate in Blood After Recreational Doses are Best Described by Zero-Order Rather Than First-Order Kinetics
نویسندگان
چکیده
منابع مشابه
Concentration-time profiles of gamma-hydroxybutyrate in blood after recreational doses are best described by zero-order rather than first-order kinetics.
The recreational drug gamma-hydroxybutyrate (GHB) has a short plasma elimination half-life (t(1/2)) reported to be about 30-50 min. However, this represents a terminal half-life and therefore might not necessarily apply after large (abuse) doses are taken. Clinical studies with sodium oxybate (sodium salt of GHB) suggest that zero-order rather than first-order kinetics are more appropriate to d...
متن کاملGamma hydroxybutyrate--a coma inducing recreational drug.
The effects of gamma hydroxybutyrate, a coma inducing recreational drug, are described and illustrated by case reports of five patients presenting to accident and emergency (A&E). All had depressed levels of consciousness. There was strong circumstantial evidence of gamma hydroxybutyrate ingestion in all cases, and laboratory evidence in two. All recovered and supportive treatment. gamma Hydrox...
متن کاملEffect of non-fiber carbohydrates on in vitro first order kinetics disappearance of cellulose
An in vitro experiment was conducted to determine the effect of supplemental non-fiber carbohydrate(NFC) on the disappearance kinetics of cellulose (Ce) by mixed ruminal microorganisms. Non-supplementedor NFC supplemented cellulose (467 mg NFC/g cellulose as sucrose (CeSu) or starch (CeSt) or a 1:1 mixtureof sucrose + starch (CeSuSt)) were incubated for 24, 48, and 96 h at 39°C. After each incu...
متن کاملSoybean Oil Transesterification Reactions in the Presence of Mussel Shell: Pseudo-First Order Kinetics
Calcium oxide is one of the appropriate catalysts for biodiesel production. In this study, cheap and compatible with environment catalyst has been used. Mussel shell of Persian Gulf coast is one of the sources of calcium carbonate that is converted to calcium oxide at calcination temperature up to 950°C. Transesterification reaction was carried out at optimum condition of our previous study...
متن کاملFirst order linear fuzzy dynamic equations on time scales
In this paper, we study the concept of generalized differentiability for fuzzy-valued functions on time scales. Usingthe derivative of the product of two functions, we provide solutions to first order linear fuzzy dynamic equations. Wepresent some examples to illustrate our results.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Analytical Toxicology
سال: 2009
ISSN: 1945-2403,0146-4760
DOI: 10.1093/jat/33.6.332